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MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
Hasan P, Berezhnaya E, Rodríguez-Prados M, Weaver D, Bekeova C, Cartes-Saavedra B, Birch E, Beyer AM, Santos JH, Seifert EL, Elrod JW, Hajnóczky G. Hasan P, et al. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2402491121. doi: 10.1073/pnas.2402491121. Epub 2024 Aug 20. Proc Natl Acad Sci U S A. 2024. PMID: 39163336 Free PMC article.
TMEM65 regulates NCLX-dependent mitochondrial calcium efflux.
Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. Garbincius JF, et al. bioRxiv [Preprint]. 2023 Oct 9:2023.10.06.561062. doi: 10.1101/2023.10.06.561062. bioRxiv. 2023. Update in: Nat Metab. 2025 Apr;7(4):714-729. doi: 10.1038/s42255-025-01250-9. PMID: 37873405 Free PMC article. Updated. Preprint.
TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux.
Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. Garbincius JF, et al. Nat Metab. 2025 Apr;7(4):714-729. doi: 10.1038/s42255-025-01250-9. Epub 2025 Apr 8. Nat Metab. 2025. PMID: 40200126 Free PMC article.
Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.
13 results