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The following term was not found in PubMed: R01AG042188
Page 1
Molecular mechanisms of aging and anti-aging strategies.
Li Y, Tian X, Luo J, Bao T, Wang S, Wu X. Li Y, et al. Cell Commun Signal. 2024 May 24;22(1):285. doi: 10.1186/s12964-024-01663-1. Cell Commun Signal. 2024. PMID: 38790068 Free PMC article. Review.
These age-related changes may be alleviated by intervention strategies, such as calorie restriction, improved sleep quality, enhanced physical activity, and targeted longevity genes. In this review, we summarise the key historical progress in the exploration of impo …
These age-related changes may be alleviated by intervention strategies, such as calorie restriction, improved sleep quality, enhanced physic …
Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster.
Li JQ, Duan DD, Zhang JQ, Zhou YZ, Qin XM, Du GH, Gao L. Li JQ, et al. Mol Genet Genomics. 2019 Dec;294(6):1463-1475. doi: 10.1007/s00438-019-01589-1. Epub 2019 Jul 20. Mol Genet Genomics. 2019. PMID: 31327054
As increasing numbers of pro-longevity genes and anti-longevity genes have been discovered in Drosophila, screening for functionally important genes among the large number of genes has become difficult. ...Overall, our results revealed th …
As increasing numbers of pro-longevity genes and anti-longevity genes have been discovered in Drosophila, screen …
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence.
Tang H, Yang J, Xu J, Zhang W, Geng A, Jiang Y, Mao Z. Tang H, et al. EMBO Rep. 2024 Aug;25(8):3263-3275. doi: 10.1038/s44319-024-00176-9. Epub 2024 Jun 12. EMBO Rep. 2024. PMID: 38866979 Free PMC article.
The enrichment of PAX5 at the 5'-UTR promotes cellular senescence and SASP by activating LINE1. We also demonstrate that the longevity gene SIRT6 suppresses PAX5 transcription by directly binding to the PAX5 promoter, and overexpressing PAX5 abrogates the suppressive effec …
The enrichment of PAX5 at the 5'-UTR promotes cellular senescence and SASP by activating LINE1. We also demonstrate that the longevity …
Tree Longevity: Multifaceted Genetic Strategies and Beyond.
Liu S, Xu H, Wang G, Jin B, Cao F, Wang L. Liu S, et al. Plant Cell Environ. 2025 Jan;48(1):244-259. doi: 10.1111/pce.15146. Epub 2024 Sep 10. Plant Cell Environ. 2025. PMID: 39254418 Review.
We summarize the contributions of physiological characteristics, stem cell activity, and immune system responses to their extraordinary longevity. We also explore the genetic and epigenetic 'longevity code', which consists of resistance and defense genes, DNA …
We summarize the contributions of physiological characteristics, stem cell activity, and immune system responses to their extraordinary l …
Eliminating malaria vectors with precision-guided sterile males.
Apte RA, Smidler AL, Pai JJ, Chow ML, Chen S, Mondal A, Sánchez C HM, Antoshechkin I, Marshall JM, Akbari OS. Apte RA, et al. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2312456121. doi: 10.1073/pnas.2312456121. Epub 2024 Jun 25. Proc Natl Acad Sci U S A. 2024. PMID: 38917000 Free PMC article.
Using a binary CRISPR strategy, we cross separate engineered Cas9 and gRNA strains to disrupt male-fertility and female-essential genes, yielding >99.5% male sterility and >99.9% female lethality in hybrid progeny. We demonstrate that these genetically sterilized mal …
Using a binary CRISPR strategy, we cross separate engineered Cas9 and gRNA strains to disrupt male-fertility and female-essential genes …
Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats.
Tello-Palencia MA, Yang T, Sularz O, Demers LE, Ma Y, Boycott C, Zhang HA, Lubecka-Gajewska K, Kumar S, Ramsey BS, Torregrosa-Allen S, Elzey BD, Lanman NA, Korthauer K, Stefanska B. Tello-Palencia MA, et al. Mol Nutr Food Res. 2024 Dec;68(24):e2400662. doi: 10.1002/mnfr.202400662. Epub 2024 Nov 19. Mol Nutr Food Res. 2024. PMID: 39562169 Free PMC article.
In recent reports, phytoestrogens attenuate age-related diseases; however, their pro-longevity effects in healthy models in mammals remain unknown. As longevity research demonstrates age-related transcriptomic signatures in human blood, the current study hypothesize …
In recent reports, phytoestrogens attenuate age-related diseases; however, their pro-longevity effects in healthy models in mammals r …
Research of recombinant influenza A virus as a vector for Mycoplasma pneumoniae P1a and P30a.
Yu L, Yongbo W, Shengjun Y, Jia T, Ya X, Guoyang L, Linna M. Yu L, et al. Immun Inflamm Dis. 2024 Sep;12(9):e70021. doi: 10.1002/iid3.70021. Immun Inflamm Dis. 2024. PMID: 39291404 Free PMC article.
BACKGROUND: Mycoplasma pneumoniae (MP) is a common respiratory pathogen affecting the longevity of the elderly and the health of children. However, the human vaccine against MP has not been successfully developed till now due to the poor immunogenicity and side effects of …
BACKGROUND: Mycoplasma pneumoniae (MP) is a common respiratory pathogen affecting the longevity of the elderly and the health of chil …
Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice.
Zhu TY, Hu P, Mi YH, Zhang JL, Xu AN, Gao MT, Zhang YY, Shen SB, Yang GM, Pan Y. Zhu TY, et al. Aging Cell. 2025 Apr;24(4):e14445. doi: 10.1111/acel.14445. Epub 2024 Dec 11. Aging Cell. 2025. PMID: 39660787 Free PMC article.
Additionally, TertKI mice exhibited robust resistance to the progression of colitis induced by dextran sodium sulfate (DSS), accompanied by reduced expression of disease-deteriorating genes. These findings foreshadow the potential of TertKI as an extraordinary rejuvenation …
Additionally, TertKI mice exhibited robust resistance to the progression of colitis induced by dextran sodium sulfate (DSS), accompanied by …
Icaritin greatly attenuates β-amyloid-induced toxicity in vivo.
Li L, Wei Z, Tang Y, Jin M, Yao H, Li X, Li Q, Tan J, Xiao B. Li L, et al. CNS Neurosci Ther. 2024 Apr;30(4):e14527. doi: 10.1111/cns.14527. Epub 2023 Nov 21. CNS Neurosci Ther. 2024. PMID: 37990437 Free PMC article.
Climbing ability, flight ability, and longevity were used to evaluate the effects of Icaritin on AD phenotypes. Abeta(arc) was determined by immunostaining and ELISA. ...Importantly, transcriptome analysis and qRT-PCR verifications showed that many key genes, direct …
Climbing ability, flight ability, and longevity were used to evaluate the effects of Icaritin on AD phenotypes. Abeta(arc) was determ …
81 results