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Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors.
Swensen AC, Piehowski PD, Chen J, Chan XY, Kelly SS, Petyuk VA, Moore RJ, Nasif L, Butterworth EA, Atkinson MA, Kulkarni RN, Campbell-Thompson M, Mathews CE, Qian WJ. Swensen AC, et al. Diabetologia. 2025 Jul;68(7):1463-1475. doi: 10.1007/s00125-025-06417-3. Epub 2025 Jun 2. Diabetologia. 2025. PMID: 40457096 Free PMC article.