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Neurotoxic reactive astrocytes induce cell death via saturated lipids.
Guttenplan KA, Weigel MK, Prakash P, Wijewardhane PR, Hasel P, Rufen-Blanchette U, Münch AE, Blum JA, Fine J, Neal MC, Bruce KD, Gitler AD, Chopra G, Liddelow SA, Barres BA. Guttenplan KA, et al. Nature. 2021 Nov;599(7883):102-107. doi: 10.1038/s41586-021-03960-y. Epub 2021 Oct 6. Nature. 2021. PMID: 34616039 Free PMC article.
Cardiovascular disease in diabetes, beyond glucose.
Eckel RH, Bornfeldt KE, Goldberg IJ. Eckel RH, et al. Cell Metab. 2021 Aug 3;33(8):1519-1545. doi: 10.1016/j.cmet.2021.07.001. Epub 2021 Jul 21. Cell Metab. 2021. PMID: 34289375 Free PMC article. Review.
Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy.
Lightbourne M, Startzell M, Bruce KD, Brite B, Muniyappa R, Skarulis M, Shamburek R, Gharib AM, Ouwerkerk R, Walter M, Eckel RH, Brown RJ. Lightbourne M, et al. J Clin Lipidol. 2022 Nov-Dec;16(6):850-862. doi: 10.1016/j.jacl.2022.06.011. Epub 2022 Sep 22. J Clin Lipidol. 2022. PMID: 36195542 Free PMC article. Clinical Trial.