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The RAS-Effector Interaction as a Drug Target.
Keeton AB, Salter EA, Piazza GA. Keeton AB, et al. Cancer Res. 2017 Jan 15;77(2):221-226. doi: 10.1158/0008-5472.CAN-16-0938. Epub 2017 Jan 6. Cancer Res. 2017. PMID: 28062402 Free PMC article. Review.
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.
Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, Valiyaveettil J, Chen X, Keeton AB, Piazza GA. Zhu B, et al. Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050202 Free PMC article.