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Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM.
Sci Adv. 2025 Feb 28;11(9):eadr1481. doi: 10.1126/sciadv.adr1481. Epub 2025 Feb 26.
Sci Adv. 2025.
PMID: 40009687
Free PMC article.
Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM.
Jimenez-Macias JL, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, Sun M, Schmidt A, Clark J, Hawkins W, Mercado N, Real J, Huntington K, Zdioruk M, Nowicki MO, Cho CF, Wu B, Li W, Logan T, Manz KE, Pennell KD, Fedeles BI, Brodsky AS, Lawler SE.
Jimenez-Macias JL, et al.
bioRxiv [Preprint]. 2024 Aug 28:2024.08.26.609797. doi: 10.1101/2024.08.26.609797.
bioRxiv. 2024.
Update in:
Sci Adv. 2025 Feb 28;11(9):eadr1481. doi: 10.1126/sciadv.adr1481.
PMID: 39253453
Free PMC article.
Updated.
Preprint.
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PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models.
Zdioruk M, Jimenez-Macias JL, Nowicki MO, Manz KE, Pennell KD, Koch MS, Finkelberg T, Wu B, Boucher P, Takeda Y, Li W, Piranlioglu R, Ling AL, Chiocca EA, Lawler SE.
Zdioruk M, et al.
Cell Rep Med. 2023 May 16;4(5):101019. doi: 10.1016/j.xcrm.2023.101019. Epub 2023 Apr 14.
Cell Rep Med. 2023.
PMID: 37060903
Free PMC article.
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