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64 results

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Page 1
Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic.
Zhao X, Xu X, Yan Y, Lipnicki DM, Pang T, Crawford JD, Chen C, Cheng CY, Venketasubramanian N, Chong E, Blay SL, Lima-Costa MF, Castro-Costa E, Lipton RB, Katz MJ, Ritchie K, Scarmeas N, Yannakoulia M, Kosmidis MH, Gureje O, Ojagbemi A, Bello T, Hendrie HC, Gao S, Guerra RO, Auais M, Gomez JF, Rolandi E, Davin A, Rossi M, Riedel-Heller SG, Löbner M, Roehr S, Ganguli M, Jacobsen EP, Chang CH, Aiello AE, Ho R, Sanchez-Juan P, Valentí-Soler M, Ser TD, Lobo A, De-la-Cámara C, Lobo E, Sachdev PS, Xu X; for Cohort Studies of Memory in an International Consortium (COSMIC). Zhao X, et al. Lancet Reg Health West Pac. 2024 Sep 12;51:101198. doi: 10.1016/j.lanwpc.2024.101198. eCollection 2024 Oct. Lancet Reg Health West Pac. 2024. PMID: 39308753 Free PMC article.
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease.
Bellaver B, Povala G, Ferreira PCL, Ferrari-Souza JP, Leffa DT, Lussier FZ, Benedet AL, Ashton NJ, Triana-Baltzer G, Kolb HC, Tissot C, Therriault J, Servaes S, Stevenson J, Rahmouni N, Lopez OL, Tudorascu DL, Villemagne VL, Ikonomovic MD, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Aizenstein HJ, Klunk WE, Snitz BE, Maki P, Thurston RC, Cohen AD, Ganguli M, Karikari TK, Rosa-Neto P, Pascoal TA. Bellaver B, et al. Nat Med. 2023 Jul;29(7):1775-1781. doi: 10.1038/s41591-023-02380-x. Epub 2023 May 29. Nat Med. 2023. PMID: 37248300 Free PMC article.
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease.
Gonzalez-Ortiz F, Kirsebom BE, Contador J, Tanley JE, Selnes P, Gísladóttir B, Pålhaugen L, Suhr Hemminghyth M, Jarholm J, Skogseth R, Bråthen G, Grøndtvedt G, Bjørnerud A, Tecelao S, Waterloo K, Aarsland D, Fernández-Lebrero A, García-Escobar G, Navalpotro-Gómez I, Turton M, Hesthamar A, Kac PR, Nilsson J, Luchsinger J, Hayden KM, Harrison P, Puig-Pijoan A, Zetterberg H, Hughes TM, Suárez-Calvet M, Karikari TK, Fladby T, Blennow K. Gonzalez-Ortiz F, et al. Nat Commun. 2024 Apr 4;15(1):2908. doi: 10.1038/s41467-024-47286-5. Nat Commun. 2024. PMID: 38575616 Free PMC article.
Trajectory of Cognitive Decline Before and After Stroke in 14 Population Cohorts.
Lo JW, Crawford JD, Lipnicki DM, Lipton RB, Katz MJ, Preux PM, Guerchet M, d'Orsi E, Quialheiro A, Rech CR, Ritchie K, Skoog I, Najar J, Sterner TR, Rolandi E, Davin A, Rossi M, Riedel-Heller SG, Pabst A, Röhr S, Ganguli M, Jacobsen E, Snitz BE, Anstey KJ, Aiello AE, Brodaty H, Kochan NA, Chen YC, Chen JH, Sanchez-Juan P, Del Ser T, Valentí M, Lobo A, De-la-Cámara C, Lobo E, Sachdev PS. Lo JW, et al. JAMA Netw Open. 2024 Oct 1;7(10):e2437133. doi: 10.1001/jamanetworkopen.2024.37133. JAMA Netw Open. 2024. PMID: 39356504 Free PMC article.
Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease.
Islam T, Hill E, Abrahamson EE, Servaes S, Smirnov DS, Zeng X, Sehrawat A, Chen Y, Kac PR, Kvartsberg H, Olsson M, Sjons E, Gonzalez-Ortiz F, Therriault J, Tissot C, Del Popolo I, Rahmouni N, Richardson A, Mitchell V, Zetterberg H, Pascoal TA, Lashley T, Wall MJ, Galasko D, Rosa-Neto P, Ikonomovic MD, Blennow K, Karikari TK. Islam T, et al. Nat Med. 2025 Feb;31(2):574-588. doi: 10.1038/s41591-024-03400-0. Epub 2025 Feb 10. Nat Med. 2025. PMID: 39930142 Free PMC article.
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease.
Gonzalez-Ortiz F, Ferreira PCL, González-Escalante A, Montoliu-Gaya L, Ortiz-Romero P, Kac PR, Turton M, Kvartsberg H, Ashton NJ, Zetterberg H, Harrison P, Bellaver B, Povala G, Villemagne VL, Pascoal TA, Ganguli M, Cohen AD, Minguillon C, Contador J, Suárez-Calvet M, Karikari TK, Blennow K. Gonzalez-Ortiz F, et al. Alzheimers Dement. 2024 Feb;20(2):1239-1249. doi: 10.1002/alz.13525. Epub 2023 Nov 17. Alzheimers Dement. 2024. PMID: 37975513 Free PMC article.
Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.
Gong J, Harris K, Lipnicki DM, Castro-Costa E, Lima-Costa MF, Diniz BS, Xiao S, Lipton RB, Katz MJ, Wang C, Preux PM, Guerchet M, Gbessemehlan A, Ritchie K, Ancelin ML, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Kosmidis MH, Guaita A, Rolandi E, Davin A, Gureje O, Trompet S, Gussekloo J, Riedel-Heller S, Pabst A, Röhr S, Shahar S, Singh DKA, Rivan NFM, Boxtel MV, Köhler S, Ganguli M, Chang CC, Jacobsen E, Haan M, Ding D, Zhao Q, Xiao Z, Narazaki K, Chen T, Chen S, Ng TP, Gwee X, Numbers K, Mather KA, Scazufca M, Lobo A, De-la-Cámara C, Lobo E, Sachdev PS, Brodaty H, Hackett ML, Peters SAE, Woodward M; Cohort Studies of Memory in an International Consortium (COSMIC). Gong J, et al. Alzheimers Dement. 2023 Aug;19(8):3365-3378. doi: 10.1002/alz.12962. Epub 2023 Feb 15. Alzheimers Dement. 2023. PMID: 36790027 Free PMC article.
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression.
Duggan MR, Gomez GT, Joynes CM, Bilgel M, Chen J, Fattorelli N, Hohman TJ, Mancuso R, Cordon J, Castellano T, Koran MEI, Candia J, Lewis A, Moghekar A, Ashton NJ, Kac PR, Karikari TK, Blennow K, Zetterberg H, Martinez-Muriana A, De Strooper B, Thambisetty M, Ferrucci L, Gottesman RF, Coresh J, Resnick SM, Walker KA. Duggan MR, et al. Brain Behav Immun. 2024 Aug;120:604-619. doi: 10.1016/j.bbi.2024.07.002. Epub 2024 Jul 6. Brain Behav Immun. 2024. PMID: 38977137 Free article.
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease.
Zeng X, Lafferty TK, Sehrawat A, Chen Y, Ferreira PCL, Bellaver B, Povala G, Kamboh MI, Klunk WE, Cohen AD, Lopez OL, Ikonomovic MD, Pascoal TA, Ganguli M, Villemagne VL, Snitz BE, Karikari TK. Zeng X, et al. medRxiv [Preprint]. 2024 Jun 16:2024.06.15.24308975. doi: 10.1101/2024.06.15.24308975. medRxiv. 2024. Update in: Mol Neurodegener. 2024 Oct 10;19(1):68. doi: 10.1186/s13024-024-00753-5. PMID: 38947065 Free PMC article. Updated. Preprint.
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology.
Kac PR, González-Ortiz F, Emeršič A, Dulewicz M, Koutarapu S, Turton M, An Y, Smirnov D, Kulczyńska-Przybik A, Varma VR, Ashton NJ, Montoliu-Gaya L, Camporesi E, Winkel I, Paradowski B, Moghekar A, Troncoso JC, Lashley T, Brinkmalm G, Resnick SM, Mroczko B, Kvartsberg H, Gregorič Kramberger M, Hanrieder J, Čučnik S, Harrison P, Zetterberg H, Lewczuk P, Thambisetty M, Rot U, Galasko D, Blennow K, Karikari TK. Kac PR, et al. Nat Commun. 2024 Mar 23;15(1):2615. doi: 10.1038/s41467-024-46876-7. Nat Commun. 2024. PMID: 38521766 Free PMC article.
64 results