S10 OD028504/OD/NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2021	5
2022	19
2023	16
2024	12
2025	14

1

Targeting lysine acetylation readers and writers.

Zhou MM, Cole PA. Zhou MM, et al. Nat Rev Drug Discov. 2025 Feb;24(2):112-133. doi: 10.1038/s41573-024-01080-6. Epub 2024 Nov 21. Nat Rev Drug Discov. 2025. PMID: 39572658 Review.

2

Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.

Kabir M, Sun N, Hu X, Martin TC, Yi J, Zhong Y, Xiong Y, Kaniskan HÜ, Gu W, Parsons R, Jin J. Kabir M, et al. J Am Chem Soc. 2023 Jul 12;145(27):14932-14944. doi: 10.1021/jacs.3c04640. Epub 2023 Jun 26. J Am Chem Soc. 2023. PMID: 37365684 Free PMC article.

3

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.

Yu X, Li D, Kottur J, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ, Cai L, Jain R, Liu J, Aggarwal AK, Wang GG, Jin J. Yu X, et al. Sci Transl Med. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586829 Free PMC article.

4

WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.

Rialdi A, Duffy M, Scopton AP, Fonseca F, Zhao JN, Schwarz M, Molina-Sanchez P, Mzoughi S, Arceci E, Abril-Fornaguera J, Meadows A, Ruiz de Galarreta M, Torre D, Reyes K, Lim YT, Rosemann F, Khan ZM, Mohammed K, Wang X, Yu X, Lakshmanan M, Rajarethinam R, Tan SY, Jin J, Villanueva A, Michailidis E, De Jong YP, Rice CM, Marazzi I, Hasson D, Llovet JM, Sobota RM, Lujambio A, Guccione E, Dar AC. Rialdi A, et al. Nat Cancer. 2023 Aug;4(8):1157-1175. doi: 10.1038/s43018-023-00609-9. Epub 2023 Aug 3. Nat Cancer. 2023. PMID: 37537299 Free PMC article.

5

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK.

Liu J, Hu X, Luo K, Xiong Y, Chen L, Wang Z, Inuzuka H, Qian C, Yu X, Xie L, Muneer A, Zhang D, Paulo JA, Chen X, Jin J, Wei W. Liu J, et al. J Am Chem Soc. 2024 Apr 10:10.1021/jacs.4c02373. doi: 10.1021/jacs.4c02373. Online ahead of print. J Am Chem Soc. 2024. PMID: 38597345

6

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.

Wang J, Yu X, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, Jin J, Wang GG. Wang J, et al. Nat Cell Biol. 2022 Mar;24(3):384-399. doi: 10.1038/s41556-022-00850-x. Epub 2022 Feb 24. Nat Cell Biol. 2022. PMID: 35210568 Free PMC article.

7

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.

Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. Xiong Y, et al. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. J Am Chem Soc. 2022. PMID: 36448571 Free PMC article.

8

Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1.

Yi J, Li H, Chu B, Kon N, Hu X, Hu J, Xiong Y, Kaniskan HU, Jin J, Gu W. Yi J, et al. Cell Death Differ. 2023 Jul;30(7):1799-1810. doi: 10.1038/s41418-023-01180-7. Epub 2023 Jun 8. Cell Death Differ. 2023. PMID: 37291217 Free PMC article.

9

The First-In-Class Deubiquitinase-Targeting Chimera Stabilizes and Activates cGAS.

Deng Z, Chen L, Qian C, Liu J, Wu Q, Song X, Xiong Y, Wang Z, Hu X, Inuzuka H, Zhong Y, Xiang Y, Lin Y, Dung Pham N, Shi Y, Wei W, Jin J. Deng Z, et al. Angew Chem Int Ed Engl. 2025 Jan 15;64(3):e202415168. doi: 10.1002/anie.202415168. Epub 2024 Oct 17. Angew Chem Int Ed Engl. 2025. PMID: 39150898

10

Discovery of an LSD1 PROTAC degrader.

Hosseini A, Qiu X, Xiong Y, Chiang KHN, Catlett J, Kaltheuner I, Deng Z, Ghosh S, Shi Y, Jin J. Hosseini A, et al. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2425812122. doi: 10.1073/pnas.2425812122. Epub 2025 May 14. Proc Natl Acad Sci U S A. 2025. PMID: 40366693

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