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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E. Ng VH, et al. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z. Nat Commun. 2023. PMID: 37798301 Free PMC article.
An unexpected journey for BNIP3.
Delgado JM, Shoemaker CJ. Delgado JM, et al. Autophagy. 2024 Jun;20(6):1447-1448. doi: 10.1080/15548627.2024.2312038. Epub 2024 Mar 6. Autophagy. 2024. PMID: 38449384 Free PMC article.
The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling.
Kassel S, Yuan K, Bunnag N, Neitzel LR, Lu W, Schwarzkopf A, Maines B, Loberg MA, Xu G, Adams A, McCray AD, Cho A, Rockouski M, Orton G, Goldsmith L, Aronno MMA, Spencer ZT, Khan OM, Ye F, Williams C, Lebensohn AM, Rohatgi R, Wang X, Weiss VL, Hong CC, Kettenbach AN, Robbins DJ, Ahmed Y, Lee E. Kassel S, et al. Nat Commun. 2025 Jun 5;16(1):5248. doi: 10.1038/s41467-025-60535-5. Nat Commun. 2025. PMID: 40473626 Free PMC article.