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Principles and methods for transferring polygenic risk scores across global populations.
Kachuri L, Chatterjee N, Hirbo J, Schaid DJ, Martin I, Kullo IJ, Kenny EE, Pasaniuc B; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group; Witte JS, Ge T. Kachuri L, et al. Nat Rev Genet. 2024 Jan;25(1):8-25. doi: 10.1038/s41576-023-00637-2. Epub 2023 Aug 24. Nat Rev Genet. 2024. PMID: 37620596 Free PMC article. Review.
The PRIMED Consortium: Reducing disparities in polygenic risk assessment.
Kullo IJ, Conomos MP, Nelson SC, Adebamowo SN, Choudhury A, Conti D, Fullerton SM, Gogarten SM, Heavner B, Hornsby WE, Kenny EE, Khan A, Khera AV, Li Y, Martin I, Mercader JM, Ng M, Raffield LM, Reiner A, Rowley R, Schaid D, Stilp A, Wiley K, Wilson R, Witte JS, Natarajan P; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium. Kullo IJ, et al. Am J Hum Genet. 2024 Dec 5;111(12):2594-2606. doi: 10.1016/j.ajhg.2024.10.010. Epub 2024 Nov 18. Am J Hum Genet. 2024. PMID: 39561770 Free PMC article.
On powerful GWAS in admixed populations.
Hou K, Bhattacharya A, Mester R, Burch KS, Pasaniuc B. Hou K, et al. Nat Genet. 2021 Dec;53(12):1631-1633. doi: 10.1038/s41588-021-00953-5. Epub 2021 Nov 25. Nat Genet. 2021. PMID: 34824480 Free PMC article. No abstract available.
Characterizing substructure via mixture modeling in large-scale genetic summary statistics.
Stoneman HR, Price A, Trout NS, Lamont R, Tifour S, Pozdeyev N; Colorado Center for Personalized Medicine; Crooks K, Lin M, Rafaels N, Gignoux CR, Marker KM, Hendricks AE. Stoneman HR, et al. bioRxiv [Preprint]. 2024 May 13:2024.01.29.577805. doi: 10.1101/2024.01.29.577805. bioRxiv. 2024. Update in: Am J Hum Genet. 2025 Feb 06;112(2):235-253. doi: 10.1016/j.ajhg.2024.12.007. PMID: 38766180 Free PMC article. Updated. Preprint.
32 results