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Precise genomic deletions using paired prime editing.
Choi J, Chen W, Suiter CC, Lee C, Chardon FM, Yang W, Leith A, Daza RM, Martin B, Shendure J. Choi J, et al. Nat Biotechnol. 2022 Feb;40(2):218-226. doi: 10.1038/s41587-021-01025-z. Epub 2021 Oct 14. Nat Biotechnol. 2022. PMID: 34650269 Free PMC article.
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.
Gasperini M, Hill AJ, McFaline-Figueroa JL, Martin B, Kim S, Zhang MD, Jackson D, Leith A, Schreiber J, Noble WS, Trapnell C, Ahituv N, Shendure J. Gasperini M, et al. Cell. 2019 Jan 10;176(1-2):377-390.e19. doi: 10.1016/j.cell.2018.11.029. Epub 2019 Jan 3. Cell. 2019. PMID: 30612741 Free PMC article.
On the design of CRISPR-based single-cell molecular screens.
Hill AJ, McFaline-Figueroa JL, Starita LM, Gasperini MJ, Matreyek KA, Packer J, Jackson D, Shendure J, Trapnell C. Hill AJ, et al. Nat Methods. 2018 Apr;15(4):271-274. doi: 10.1038/nmeth.4604. Epub 2018 Feb 19. Nat Methods. 2018. PMID: 29457792 Free PMC article.
Massively parallel characterization of regulatory elements in the developing human cortex.
Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM; PsychENCODE Consortium‡; Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS; PsychENCODE Consortium. Deng C, et al. Science. 2024 May 24;384(6698):eadh0559. doi: 10.1126/science.adh0559. Epub 2024 May 24. Science. 2024. PMID: 38781390 Free PMC article.
Massively parallel characterization of transcriptional regulatory elements.
Agarwal V, Inoue F, Schubach M, Penzar D, Martin BK, Dash PM, Keukeleire P, Zhang Z, Sohota A, Zhao J, Georgakopoulos-Soares I, Noble WS, Yardımcı GG, Kulakovskiy IV, Kircher M, Shendure J, Ahituv N. Agarwal V, et al. Nature. 2025 Mar;639(8054):411-420. doi: 10.1038/s41586-024-08430-9. Epub 2025 Jan 15. Nature. 2025. PMID: 39814889 Free PMC article.
41 results