AMPAR inhibition lowers S1P in human blood and improves murine autoimmune neuroinflammation by blocking T cell egress from lymph nodes.
Wasser B, Ecker M, Hanuscheck N, Ellwardt E, Gärtner Y, Engeroff K, Domingues M, Grünewald B, Oshaghi M, Wollnitzke P, Schroeter CB, Schmidt MHH, Muthuraman M, Levkau B, Winter Y, Meuth SG, Nitsch R, von Engelhardt J, Bittner S, Zipp F.
Wasser B, et al. Among authors: ellwardt e.
Sci Transl Med. 2025 Jun 11;17(802):eads6434. doi: 10.1126/scitranslmed.ads6434. Epub 2025 Jun 11.
Sci Transl Med. 2025.
PMID: 40498853