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Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.
Yu KO, Randolph AG, Agan AA, Yip WK, Truemper EJ, Weiss SL, Ackerman KG, Schwarz AJ, Giuliano JS Jr, Hall MW, Bubeck Wardenburg J; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICFlu Study Group; PALISI PICFlu Study Group. Yu KO, et al. J Infect Dis. 2016 Dec 1;214(11):1638-1646. doi: 10.1093/infdis/jiw441. Epub 2016 Sep 20. J Infect Dis. 2016. PMID: 27651418 Free PMC article.
In mice, S. aureus alpha-toxin directly injures pneumocytes and increases mortality, whereas alpha-toxin blockade mitigates disease. The role of alpha-toxin in pediatric staphylococcal-viral coinfection is unclear. METHODS: We enrolled children across 34 North American …
In mice, S. aureus alpha-toxin directly injures pneumocytes and increases mortality, whereas alpha-toxin blockade mitigates disease. The rol …
Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection.
Randolph AG, Agan AA, Flanagan RF, Meece JK, Fitzgerald JC, Loftis LL, Truemper EJ, Li S, Ferdinands JM; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICFlu Study Group. Randolph AG, et al. Pediatr Crit Care Med. 2016 Apr;17(4):279-86. doi: 10.1097/PCC.0000000000000661. Pediatr Crit Care Med. 2016. PMID: 26895562
DESIGN: Prospective cohort study. SETTING: PICUs at 21 tertiary pediatric referral centers in the United States. PATIENTS: During the 2010-2011 and 2011-2012 influenza seasons, we enrolled children (6 mo to 17 yr old) who were suspected to have severe viral infection. ...
DESIGN: Prospective cohort study. SETTING: PICUs at 21 tertiary pediatric referral centers in the United States. PATIENTS: During the …