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Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).
Baker LD, Snyder HM, Espeland MA, Whitmer RA, Kivipelto M, Woolard N, Katula J, Papp KV, Ventrelle J, Graef S, Hill MA, Rushing S, Spell J, Lovato L, Felton D, Williams BJ, Ghadimi Nouran M, Raman R, Ngandu T, Solomon A, Wilmoth S, Cleveland ML, Williamson JD, Lambert KL, Tomaszewski Farias S, Day CE, Tangney CC, Gitelman DR, Matongo O, Reynolds T, Pavlik VN, Yu MM, Alexander AS, Elbein R, McDonald AM, Salloway S, Wing RR, Antkowiak S, Morris MC, Carrillo MC; U.S. POINTER Study Group. Baker LD, et al. Alzheimers Dement. 2024 Feb;20(2):769-782. doi: 10.1002/alz.13365. Epub 2023 Sep 30. Alzheimers Dement. 2024. PMID: 37776210 Free PMC article. Clinical Trial.
Baseline characteristics of the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER): Successful enrollment of a diverse clinical trial cohort at risk for cognitive decline.
Whitmer RA, Baker LD, Carrillo MC, Snyder HM, Cleveland ML, Gitelman DR, Kivipelto M, Leng XI, Lovato L, Papp KV, Pavlik VN, Salloway SP, Tangney CC, Farias ST, Williamson JD, Wilmoth S, Woolard N, Yu M, Espeland MA; U.S. POINTER Study Group. Whitmer RA, et al. Alzheimers Dement. 2025 Jun;21(6):e70351. doi: 10.1002/alz.70351. Alzheimers Dement. 2025. PMID: 40556311 Free PMC article. Clinical Trial.
The POINTER Imaging baseline cohort: Associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition.
Harrison TM, Ward T, Taggett J, Maillard P, Lockhart SN, Jung Y, Lovato LC, Koeppe R, Jagust WJ, Harvey D, Masdeu JC, Oh H, Gitelman DR, Aggarwal NT, Espeland MA, Cleveland ML, Whitmer R, Farias ST, Salloway S, Pavlik V, Yu M, Tangney C, Snyder H, Carrillo M, Baker LD, Vemuri P, DeCarli C, Landau SM; U.S. POINTER Study Group. Harrison TM, et al. Alzheimers Dement. 2025 Jan;21(1):e14399. doi: 10.1002/alz.14399. Epub 2024 Dec 6. Alzheimers Dement. 2025. PMID: 39641363 Free PMC article.
Optimizing quantification of MK6240 tau PET in unimpaired older adults.
Harrison TM, Ward TJ, Murphy A, Baker SL, Dominguez PA, Koeppe R, Vemuri P, Lockhart SN, Jung Y, Harvey DJ, Lovato L, Toga AW, Masdeu J, Oh H, Gitelman DR, Aggarwal N, Snyder HM, Baker LD, DeCarli C, Jagust WJ, Landau SM; U.S. POINTER Study Group. Harrison TM, et al. Neuroimage. 2023 Jan;265:119761. doi: 10.1016/j.neuroimage.2022.119761. Epub 2022 Nov 28. Neuroimage. 2023. PMID: 36455762 Free PMC article. Clinical Trial.
Positron emission tomography harmonization in the Alzheimer's Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification.
Landau SM, Harrison TM, Baker SL, Boswell MS, Lee J, Taggett J, Ward TJ, Chadwick T, Murphy A, DeCarli C, Schwarz CG, Vemuri P, Jack CR Jr, Koeppe RA, Jagust WJ; U.S. POINTER Study Group and for the Alzheimer's Disease Neuroimaging Initiative. Landau SM, et al. Alzheimers Dement. 2025 Jan;21(1):e14378. doi: 10.1002/alz.14378. Epub 2024 Nov 19. Alzheimers Dement. 2025. PMID: 39559932 Free PMC article.